Regulating Cross-Talk Between Vascular Smooth Muscle Cells
نویسندگان
چکیده
منابع مشابه
Regulating cross-talk between vascular smooth muscle cells.
Gap junctions are small pore-forming protein connections between neighboring cells that mediate the flow of ions and small molecules ( 1 200 Da). As such, they provide a degree of direct cytoplasmic continuity between cells that contributes, along with paracrine pathways, to the intercellular flow of information. These channels are often thought to be long-lived, nonspecific conduits allowing t...
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OBJECTIVE Our aim was to examine the possible cross-talk of angiotensin II (Ang II) and aldosterone (Aldo) in the regulation of vascular cell senescence in cultured vascular smooth muscle cells (VSMC). METHODS VSMC were prepared from thoracic aorta of adult male Sprague-Dawley rats. Cellular senescence was evaluated by senescence-associated beta-galactosidase (SA-beta-gal) staining and expres...
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OBJECTIVE Interleukin (IL)-1β and IL-18 are key proinflammatory cytokines that play important roles in the pathophysiology of vein graft remodeling. However, the mechanism of IL-1β/IL-18 production and its role in the development of graft remodeling remain unclear. APPROACH AND RESULTS IL-1β/IL-18 were rapidly expressed in venous interposition grafts. Vascular smooth muscle cell (VSMC) death ...
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BACKGROUND The mechanism of pulmonary artery smooth muscle cell (PA-SMC) hyperplasia in idiopathic pulmonary artery hypertension (iPH) may involve both an inherent characteristic of PA-SMCs and abnormal control by external stimuli. We investigated the role of pulmonary microvascular endothelial cells (P-ECs) in controlling PA-SMC growth. METHODS AND RESULTS Serum-free medium of quiescent P-EC...
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The response of blood vessels to physiological and pathological stimuli partly depends on the cross talk between endothelial cells (EC) lining the luminal side and smooth muscle cells (SMC) building the inner part of the vascular wall. Thus, the in vitro analysis of the pathophysiology of blood vessels requires coculture systems of EC and SMC. We have developed and validated a modified three-di...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2003
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000093820.81258.5f